Maximal Acid Output and Risk of Ulcer Sir

assay (R.I.A.) for estimation of plasma concentrations of nortriptyline and amitriptyline in monitoring response of patients receiving these drugs. However, a wide range of monoaminereuptake-inhibiting drugs is now used in treatment of depressive illness, and an advantage of some other analytical methods, such as the gas-liquid chromatography method described by Gifford et al.,’ is that they can readily estimate most of these drugs and their main metabolites2 as well as identify some other centrally acting drugs such as benzodiazepines which the patient may be taking. For example, in a comparative study of two antidepressive.drugs, we found that some patients had been given the wrong drug and some were found to